2,2-DIMETHYLGLUTARIC ANHYDRIDE

2,2-DIMETHYLGLUTARIC ANHYDRIDE - Names and Identifiers

Name	2,2-Dimethylglutaric anhydride
Synonyms	2,2-DIMETHYLGLUTARIC ANHYDRIDE 2,2-Dimethylglutaric anhydride ALPHA,ALPHA-DIMETHYLGLUTARIC ANHYDRIDE 3,3-dimethyltetrahydro-2H-pyran-2,6-dione 3,3-Dimethyldihydro-2H-pyran-2,6(3H)-dione dihydro-3,3-dimethyl-2H-pyran-2,6(3H)-dione 2H-Pyran-2,6(3H)-dione, dihydro-3,3-dimethyl-
CAS	2938-48-9
EINECS	220-922-9
InChI	InChI=1/C7H10O3/c1-7(2)4-3-5(8)10-6(7)9/h3-4H2,1-2H3

2,2-DIMETHYLGLUTARIC ANHYDRIDE - Physico-chemical Properties

Molecular Formula	C7H10O3
Molar Mass	142.15
Density	1.1643 (rough estimate)
Melting Point	34-38 °C (lit.)
Boling Point	175-180 °C/60 mmHg (lit.)
Flash Point	>230°F
Vapor Presure	0.0083mmHg at 25°C
Appearance	powder to lump
Color	White to Almost white
BRN	117056
Storage Condition	Room Temprature
Sensitive	Moisture Sensitive
Refractive Index	1.4730 (estimate)
MDL	MFCD00006682

2,2-DIMETHYLGLUTARIC ANHYDRIDE - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29171990

2,2-DIMETHYLGLUTARIC ANHYDRIDE - Reference Information

use

2,2-dimethylglutaric anhydride is an organic intermediate. it is reported in the literature that 2,2-dimethylglutaric anhydride can be used to prepare a high molecular weight aliphatic polyester.

Preparation

2,2-dimethylglutaric anhydride can be obtained by reacting with a condensing agent from 2,2-dimethylglutaric acid as raw material. 2, 2-dimethylglutaric acid (3.00g,18.7 mmol) was added to a dichloromethane (360 mL) solution of EDCI(3.95g,20.6 mmol) and triethylamine (2.87 mL,20.6 mmol) and the reaction mixture was stirred for 18 h at room temperature. The solution was washed with saturated NaHCO3 aqueous solution (2 × 100mL) and water (1 × 100mL). The organic layer is dried by anhydrous magnesium sulfate, filtered and concentrated. The crude product was purified by rapid silica chromatography using ethyl acetate and hexane (30 ∶ 70) as eluents to give a white solid (1.88g,71%).

Last Update：2024-04-10 22:29:15